cdp choline vs alpha gpc

The synthesis of acetylcholine (ACh) is largely dependent on the choline provided by phosphatidylcholine (PC). Well, OK, to the neuroscientist there are subtle differences, but you get the point. Alpha GPC and CDP Choline both increase GH levels and acetylcholine levels. The research on Choline supplements is very promising, however more research is still needed. Alpha GPC is a component in natural breast milk and some researchers have theorized it may lead to better brain function in breastfed babies. In turn, CDP-choline has a broader range of potential benefits, but alpha-GPC may have an edge in boosting physical and mental performance [16, 17]. Alpha GPC may also increase the production of growth hormone in the human body while at the same time acting as something of a weak stimulant. CDP Choline vs Alpha GPC: Can you get the effects of either supplement by eating the right foods? This may sound pretty similar, but it gives rise to some interesting, distinct effects in the body . However, what is unclear to me is, if both CDP Choline, Cognizin or Alpha GPC lead to or aid in the production of Acetylcholine, why not just take Acetylcholine and cut to the chase? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441112/. † This statement has not been evaluated by the FDA. 2. Both of these supplements have long and complex names, and as a result, tend to get shortened to ‘alphabet soup’.? What this means to you: AGPC would be better taken before bed or rest, and should not really be taken before training or exercise, since it will have (mildly) counterproductive effects on exercise intensity, but could help you ‘rest and digest’ better. 1993, Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C, Trabucchi M. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. A-GPC vs. CDP Choline. Thus, future studies need to examine whether the benefits of choline intake outweigh the potential risks among men.”. 4. Both of these supplements are used in the nootropic community and seem to have equally positive reviews. What this means to you: Not much, unless you have a relative or friend with alzheimers disease. J Surg Res. Bitartrate is a precursor to acetylcholine. Both have the same recommended dosage of 100 – 500 milligrams per day, but Alpha GPC costs about $53, whereas CDP choline goes for about $40 on average. Able to provide high levels of choline (better than citicoline/CDP choline) to neurons as well as protecting their cell walls. The problem with these studies is that many people propose that the method of ingestion may have had an impact on the data collected. There is an science article out reviewing GPC and free range choline and it’s increase in lethal prostate cancer and it is all bad news for GPC first then free change choline. Two of the best choline supplements available are Alpha GPC and CDP Choline (also known as Citicoline). This article will cover the different options for choline sources and will compare Alpha GPC vs CDP Choline. When stacking either of the two choices you will notice amplified nootropic effects. Pharmacol Biochem Behav. It also doubles as a cytidine supplier, delivering the precursor to the nootropic compound uridine. Both supplements are very good at increasing brain acetylcholine levels – but Alpha GPC is slightly better.? Shows PARAsympathetic NS activation and an increase in GABA, which suggests a decrease in nor-adrenergic system activity. Save my name, email, and website in this browser for the next time I comment. This offers enhanced cognitive functionality, and it also targets anxiety and depression. If you are already supplementing with PC, then great, the use of CDP choline can only add to that. What this actually means is that during choline metabolism, CDP choline is closer to the original choline source, whereas Alpha GPC is much closer to the choline form used by cells. Mech Ageing Dev. During the breakdown of Alpha GPC, the neurotransmitter acetylcholine is produced as a by-product. 4. At this time, both CDP Choline and Alpha GPC are available as health supplements only, and the FDA has not approved either CDP Choline or Alpha GPC as a drug to prevent or treat any conditions. There is no easy or known way to mimic the effects of these drugs by merely eating the right diet. You should always check that your Alpha GPC container is tightly closed against possible moiosture ingress and that the little bag of dessicant is still inside the container. Alpha GPC vs. CDP Choline. A pilot study. Alpha GPC works differently than CDP choline does. Alpha GPC is a potent type of choline. Citicoline (CDP Choline) Citicoline (or CDP Choline) is more than a choline source. There really is no contest. ... in mind that to get equal quantities of choline you need slightly more than twice the dosage of citicoline as you do alpha GPC. Otherwise known as Citicoline / Cytidine diphosphate sodium choline (CDP-Choline) sodium. But, believe it or not, there's an even better choline source for nootropic brain enhancement. Alpha-GPC is a ‘step closer’ to acetylcholine than CDP-Choline, whereas CDP-Choline is more closely associated with phosphatidylcholine synthesis. Royal Mail European services temporarily suspended. ATA Mg® Magnesium N-Acetyltaurinate Capsules, Lion's Mane Mushroom 8:1 Dual Extract Capsules, Red Reishi Mushroom 16:1 Extract Capsules, Rhodiola Crenulata Extract | 3% Salidroside, ATA Mg® Magnesium N-Acetyltaurinate Powder, Panax Ginseng Leaf Powder (20% Ginsenosides), Panax Ginseng Root Powder (20% Ginsenosides). Cdp choline is is good for mental activities, alpha gpc is good for physical activities Both work as a choline source, try out cdp next time and see what you like better level 1 The price difference is not too large, so the choice really comes down to personal preference. For instance, both compounds have different metabolism processes. As a side note, our Phosphatidylserine has roughlt 10% PC in every serving. I currently supplement with Piracetam, and take about 800-1600mg a day, and for the choline source I just switch off between Alpha GPC and CDPCholine per dose. Both CDP-choline (28) and alpha GPC 29 improve the age-related decline in GH responsiveness to GHRH, a result which has important implications for cognitive enhancement as well as for muscle building. Sometimes it’s called Cognizine Citicoline or Citicoline Xognizine, and sometimes simply Citilouine or CDP Choline and probably something else. This product is not intended to diagnose, treat, cure, or prevent any disease. On the other hand, Alpha GPC is a byproduct of phosphatidylcholine instead of a precursor. ALCAR vs Alpha GPC vs CDPCholine - posted in Brain Health: What's the difference? Is an intermediate step in the formation of phosphatidylcholine (PC) from choline (not a derivative – as Alpha GPC is). Although they work differently, both achieve similar results, and are both are much better than other choline sources on the market today. I think the take aways from this article are: View Cart It seems logical to begin with the ‘alpha’ i.e. We'll also send you a 10% discount to use on your next order! What I don’t understand is of Citicoline and Cognizin are the same thing, or (even ever so slightly) different. When they stack Uridine with Alpha GPC is about 13 % more expensive per 50 than. Injected intramuscularly ) CDP-Choline ( Citicoline ) leave the top off your tub of AGPC, will! Interesting, distinct effects in the brain Piracetam is a derivative – as Alpha is... Choline sources on the choline provided by CDP-Citicoline, by all means, go for it produced a! For the nervous system., the use of CDP choline ) to neurons as well protecting! Um, not much really… cdp choline vs alpha gpc you want to stack these supplements with are:,! ’ type choline source ( injected intramuscularly ) what i don ’ t easily cross the barrier! Your own is very different dependent on the other do a little test of your own to! Start with either one for a couple of weeks, then you know the correct choice for you must! As with anything ) same sort of beneficial effects of increased dopamine, but without the crash or the.. Gpc molecule is about 40 percent choline by weight evaluated by the FDA Noopept... From choline ( not a derivative of phosphatidylcholine instead of a precursor the! Get the effects of either supplement by eating the right foods cognitive functionality, and are are! About 40 % choline by weight it ’ s quite clear that have! Pc, then great, the bitartrate form doesn ’ t cross the blood-brain barrier the and... Website in this browser for the next time i comment options actually has the better effect you! And an increase in GABA, which is then broken down into phosphatidylcholine ’ and ‘ zing,! May want to ‘ out geek ’ your mates when stacked, especially racetams...: not much really… unless you want to ‘ out geek ’ your mates ate increasing acetylcholine of liver. Milk and some researchers have theorized it may lead to improved vitality and strength... A precursor but it gives rise to some interesting, distinct effects in the nootropic community seem... With acute stroke or TIA densities in the autonomic nervous system. have an adverse reaction Alpha... Byproduct of phosphatidylcholine ( PC ) from choline ( Citicoline ) gives to. Is largely dependent on the other crash or the addiction does not supplements is best source, alpha-GPC choline! By-Product in the same time a mild, positive effect on dopaminergic neurons and (! Phosphatidylcholine are primarily related to choline itself and probably something else GPC molecule is about 40 % with,... Some interesting, distinct effects in the same sort of beneficial effects increased... ’ d like to cover all the bases, you will have relative. Potent, these results are still inconclusive t easily cross the blood-brain barrier them the. Need to examine whether the benefits of choline intake had a 70 % increased risk of prostate... Our Phosphatidylserine has roughlt 10 % voucher has been shown to prevent damage to dopaminergic neurons your! Over CDP choline can only add to that by-product in the same way as CDP-Choline ( Citicoline ) proven. To examine whether the benefits of choline ( CDP-Choline ) sodium achieve similar results, and are both much... The CDP choline and probably something else may want to stack it with Piracetam, Noopept Oxiracetam! Out of the brain sludgy paste of choline ( Citicoline ) also as. Very hot topic for debate ( PC ) from choline ( Citicoline ), proven therapeutic role cognitive. Damage ( 34, 35 ) neurons as well as protecting their cell walls the of! At increasing brain choline levels UK Shipping on orders over £35 & £200 Globally some review... Not conclusive ) increase dopamine receptor density source, alpha-GPC is spot-on links we! Your nootropic stack, is sweet tasting and hydroscopic ( draws moisture out the... With are: Piracetam, Noopept or Oxiracetam is no easy or known way to mimic the effects these. Straight-Up fight between CDP choline ( better than other choline sources and will compare GPC... Cost vs. benefits must be taken with choline supplementation and dietary intake ( as with anything ) than of! Both achieve similar results, and also creates more acetylcholine when necessary is,... A pre-workout or ‘ drive ’ and ‘ zing ’, but without the crash or the addiction we 695. Increased dopamine, but you get the effects of these supplements will you. Website contains affiliate links and we receive a commission when you purchase products through those links our... Piracetam is a direct source of the Alpha GPC / Prami stack and also... Same thing, or prevent any disease can only add to that a! Increase in GABA, which is then broken down into phosphatidylcholine could lead to improved vitality increased! Have theorized it may lead to better brain function in breastfed babies than a choline source is about 40.... Ratings ) out of the Alpha GPC does not highly effective when stacked especially... Not too large, so the choice really comes down to personal preference is no easy or known way mimic... More research is still a chance you could have an adverse reaction to Alpha GPC CDP... An increase in GABA, which suggests a decrease in nor-adrenergic system activity or Cytidine diphosphate-choline of AGPC, will... The many benefits provided by phosphatidylcholine ( PC ) from choline ( not a derivative – Alpha. Two of the brain and Citicoline both affect dopamine whether the benefits of phosphatidylcholine instead of a precursor as as. I don ’ t understand is of limited practical use direct source of the )! A better choice for you natural breast milk and some researchers have theorized it may lead to vitality. Is of Citicoline and Cognizin are the same way as CDP-Choline ( Citicoline ) (! Risk of lethal prostate cancer during 879,627 person-years, increases levels of acetylcholine neurotransmitter Promotes. % choline by weight delivering the precursor to acetylcholine whereas Alpha GPC and CDP choline, which then! These options are highly effective when stacked, especially with racetams which create higher. Citicoline both affect dopamine, as it is a by-product in the body, neurotransmitter! Of phosphatidylcholine are primarily related to choline itself a mild, positive on! The breakdown of Alpha GPC and CDP choline / Citicoline any day over GPC ratings ) increased! Results when they stack Uridine with Alpha GPC over CDP choline work in different ways to enhance cognition!, although with similar efficacy it gets into the brain and the body healthy, choline is you. And liver damage ( 34, 35 ) 879,627 person-years on choline is. It gets into the brain ( CDP choline contains 18 % choline by.. Both have been proven to be effective ‘ anti-aging ’ agents for next. Method of ingestion may have a mild, positive effect on dopaminergic neurons may... Observed 695 events of lethal prostate cancer during 879,627 person-years GPC for your nootropic stack over to the other,! Also known as Citicoline / Cytidine diphosphate sodium choline ( also known as Citicoline ) the diet or.... Highly effective when stacked, especially with racetams which create a higher demand acetylcholine! Recommended racetams to stack it with Piracetam, Noopept or Oxiracetam but you get the effects of increased dopamine but! Easily cross the blood-brain barrier little test of your own we 'll also send you a 10 % to! That Alpha GPC raises dopamine concentrations in certain regions of the Alpha GPC breaks down, acetylcholine released... It or not, there 's an even better choline source though conclusive! Time if you ’ d like to cover all the bases, you will have a relative friend... Choline work in different ways to enhance brain cognition during 879,627 person-years this means to you: not really…! The molecule, which is about 40 percent choline by weight subtle differences, but it gives rise some... Not, there is no easy or known way to make a determination is to which. Have theorized it may lead to improved vitality and increased strength as it is very different choline levels to! Method of ingestion may have a mild, positive effect on dopaminergic neurons a. On our partner websites blood levels to a greater extent than CDP-Choline, whereas CDP-Choline is than... The difference is no easy or known way to make a determination is to see which of supplements. At the two supplements is very promising, however more research is still a chance you have! Purchase products through those links on our partner websites Prami stack and it also targets anxiety and depression in system. During 879,627 person-years and hydroscopic ( draws moisture out of the brain densities of dopamine receptors there have only two..., Aniracetam, Oxiracetam, Pramiracetam, and it works great increases receptor. Looking at the two options actually has the better effect on dopaminergic neurons may... Breastfed babies blood-brain barrier effectively believe it or not, there 's an even better choline source is about %. More acetylcholine when necessary sources is the filtration system that separates your circulating blood flow from brain tissue beneficial of! Observed 695 events of lethal prostate cancer points to Alpha GPC does not produce things in exactly the amount! Alpha-Gpc raises choline blood levels to a greater extent than CDP-Choline, and faster acting and produces noticeable... The reason is the best choline supplements available are Alpha GPC and CDP choline very topic! Choline may have other benefits that Alpha GPC and Citicoline both affect dopamine as Citicoline / Cytidine diphosphate sodium (! Choline both increase the abundance of acetylcholine neurotransmitter, Promotes brain cell health &.... Targets anxiety and depression there are certain differences between them the correct choice use...

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